Amniotic MSCs reduce pulmonary fibrosis by hampering lung B‐cell recruitment, retention, and maturation
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چکیده
منابع مشابه
Recruitment and retention of lung volume
Both a reduction in tidal volume and in alveolar recruitment may be necessary to prevent ventilatorinduced lung injury in the management of patients with acute respiratory distress syndrome. The lung collapse associated with endotracheal suctioning produces hypoxaemia, but it also causes derecruitment, potentially aggravating lung injury. A study conducted by Dyhr and colleagues demonstrates th...
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The fluorescence probe 1,6, diphenyl-1,3,5-hexatriene was used to determine the micro-viscosity of third trimester amniotic fluid samples utilising an Aminco Bowman spectrofluorometer fitted with a polariser prism. The results were related to the lecithin sphingomyelin (L:S) ratio. A fluorescence polarisation value of 0.360 corresponded to an L:S ratio of 2.0 in uncomplicated and diabetic preg...
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The role of mitochondrial energy metabolism in maintaining lung function is not understood. We previously observed reduced lung function in mice lacking the fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD). Here, we demonstrate that long-chain acylcarnitines, a class of lipids secreted by mitochondria when metabolism is inhibited, accumulate at the air-fluid interface in LCA...
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Bleomycin-induced lung injury has been extensively used as a model of interstitial pneumonia and pulmonary fibrosis. Intercellular adhesion molecule (ICAM)-1 is a ligand for lymphocyte function-associated antigen (LFA)-1alpha and has been shown to be required for leukocyte migration into inflamed areas. The purpose of this report was to investigate the role of the ICAM-1/LFA-1alpha pathway in a...
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ژورنال
عنوان ژورنال: STEM CELLS Translational Medicine
سال: 2020
ISSN: 2157-6564,2157-6580
DOI: 10.1002/sctm.20-0068